I made exactly the same transition some years ago - from a 172S to a
182S, and my impression is in some ways opposite to the others listed
here. The 182S was the first constant-speed prop I had flown, and I found
the plane took off like a rocket! The torque and acceleration on takeoff
took some getting used to for me. After this, you will find pretty much
the same panel, and it will not be much more difficult to fly. You'll
have the advantage of getting where you're going faster, and though
per-hour operating costs will be higher, per-mile costs are only slightly
greater. If you are not yet used to the constant-speed prop, this will be
by far the most significant issue for you, including the use of the
appropriate instrumentation (manifold pressure and RPM, instead of just
RPM). Landing? Yes, it's heavier, and you will quickly learn to take
advantage of the electric trim right under your left thumb, unless you
want your landings to take the place of your weekly workout at the gym.
If you don't have the luck I had - to land the plane for the first time
with a 25kt crosswind- it should be no big trick.

I knew the plane was heavier, so I was ready for that. You know it, and
you're ready for it. I knew about the CS prop, and had studied that too.
What surprised me was the torque on takeoff.

GF