Heck YES! Things like this is exactly why passenger carrying aircraft
have TWO pilots. Essentially, both pilots should agree, especially on
something as basic as this. If either pilot disagrees, the issue should
be worked out until there is an agreement. In a dispute, captain
prevails, but ANY good captain should carefully consider his copilot's
opinion.

wrote:
If as PNF you notice that the PF has just turned on to the wrong runway
to commence the takeoff roll, are you permitted to alert him (can't see
why not, actually, if lives are likely to be on the line) to it or are
you expected to just shut up and let him make the call? Presume for the
moment that the Capn is PF, which I hear wasn't the case in the LEX
incident...

Ramapriya