I refer the original poster to Low Power Laminar A/C Design by P.
Strojnik... A series of three books... Fascinating reading... The EAA
should have them at the book store...

But, to answer the question, the biggest impediment to the home builder
for making a monocoque fuselage in wood is the need for a plug to cold
mold or laminate the wood onto... If the fuse is symmetrical, a half
plug will work and join the two halves later... The favored material is
cement for making the plug, mostly for cost reasons I suspect - it
certainly would hamper portability...
The Mosquito was done this way, as was (I believe) much of the Spruce
Goose... Much of the Cirrus airplanes are plug molded as semi-monocoque
structures, but I don't think they use cement plugs

denny