I got to watch some sim evaluations for job interview candidates once. It
was wonderfully entertaining. The candidates came from regionals flying
glass cockpit CRJs. They were used to sprightly performance with good
power.
Their scanning skills were diminished because of the glass and the
autothrottles. The evals took place in the stretch DC-8 sim. One of
candidates actually landed close to the runway. All of them went out of
box
with a ghostly shade of gray. Very humbling.

You can get lazy using flight directors. I did some evaluations for a
start-up airline while working for Flight Safety Boeing (now Alteon).
Because the candidates normally wouldn't be experienced in the MD-80
simulator we used for the evaluation we had them fly without flight
directors, autopilot, or auto-throttles. One of the 2 pilots was flying the
MD-80 for another airline and the other pilot was a lady from a fixed base
operator with no jet time at all. I figured the MD-80 guy would do much
better than the lady. WRONG! He was so used to the MAGIC he couldn't fly
basic instruments worth a crap. The gal who normally only had basic
instruments flew much better. (but to be honest I heard one of our
instructors had let her have sim time on the side to help her prepare).