I have used XCSoar with the Air Avionics ISU. The serial stream mimics either LX or CAI protocol, and either can be used with XCSoar. Wind data is transmitted in both procotols, but in a time filtered form. However XCSoar does not seem to use that data, rather it calculates wind using its own traditional methods.

While others have claimed to have and use inertial sensors going back to the first CAI 302, it appears as though no one except Air is actually using them to a meaningful result even today.