An Airbus A340 jumped its wheel chocks and broke the tie-down chains
during an engine test, then leaped forward and into a concrete
barrier. The entire nose section broke off. The crew was injured,
but thankfully no one was killed. Brand new airplane with exactly one
flight in the log. Now it's a write-off.

http://www.airliners.net/open.file/1293784/M/