FYI: Dec 12 MythBusters: Airplane Hour

F. Baum writes:

Jim, I caught just the parts of the show where J and A tried to land
the plane with some coaching from the sim instructor (Mainly to see
how the instructor would do this). These portions of the show were
amazingly brief (Possibly for security reasons ?) . The stuff they did
show was scary and I doubt they could have gotten awhay with some of
it in a real plane. I do watch the show for its "Infotaiment" value
but I remain unconvinced that someone could actually be talked down in
an airliner. I think it has been tried a time or two in GA after the
pilot became incapacitated.

A small GA airplane is completely different from an airliner, but in any case,
it has been done successfully in small planes. No circumstances have ever
required it in airliners, but it's certainly doable.