One specific plane I have been looking at is Van's RV-10.
Any comments on this? Really have not come across any other options.

That's because there really are not many options in that class. You're
looking for a plane that is a useful traveling machine, not a toy.

The only problem with the RV-10 is that it hasn't had a chance to prove
itself yet - not many flying. On the other hand, it's been a long,
long time since Van came up with a dud. It will probably be OK. Most
of Van's designs don't carry enough fuel to be serious IFR machines (a
hard IFR flight generally calls for launching with at least 2 hours of
reserves) but I understand the RV-10 is going to have a 5+ hour range
so that should be OK.

You need to pay attention to landing speed, especially for an IFR
machine - anything that has to land much over 60 mph really needs two
engines. In the certified world, anything that has to land over 70 mph
is required to have two engines (and a certain minimum performance with
one shut down). All the slick efficient fast glass singles land at 70+
mph. I believe the RV-10 is just a bit over 60, so just on the upper
edge of tolerable if you want a fighting chance of surviving an engine
failure in IMC.

A friend of mine was looking to buy (not build) an experimental that
met pretty much your requirements. In the end, he compromised some on
speed and bought a Mooney. He just couldn't find anything sutiable in
the homebuilt arena that he could afford.

Michael