With our current brains we're making good
progress towards real genetic engineering, and one of the first things
we'll do is make ourselves smarter (as well as healthier, stronger,
and so forth)...

You mean, we'll make somebody else's children smarter... than us.
Assuming we don't screw up. By accident or on purpose.

and then when we're smarter we'll do even better
genetic and/or machine intelligence, etc.

No. When =they= are smarter, they will do whatever they want. Maybe
we'll be in the way. Maybe we'll have thought of that beforehand.

So a hundred years from now humankind [...] will be much changed

Not a chance. There won't be time in a hundred years to see whether we
screwed up or not. If humankind is "much changed", we who remain will
be exterminated. If humankind is =not= much changed, then I was right.

Jose
--
Quantum Mechanics is like this: God =does= play dice with the universe,
except there's no God, and there's no dice. And maybe there's no universe.
for Email, make the obvious change in the address.